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Goulding Lab

The Goulding lab is primarily interested in elucidating the fundamental principles that underlie the development of different interneuron cell types in the spinal cord in order to determine the contribution specific interneurons make to sensorimotor circuits. The spinal cord in general, and locomotor circuits in particular, provide an ideal model system for determining how simple neural circuits develop and derive their functional outputs. These simple motor networks are often referred to as locomotor central pattern generators (CPGs). The strategy of my lab has been to use molecular genetic tools to study the properties of particular interneuron cell types and assess the contribution that they make to motor behaviors such as locomotion and sensorimotor integration. The lab takes a multifaceted approach to circuit analysis by using a combination of genetic, anatomical, developmental and electrophysiological approaches to address the make up of spinal sensorimotor networks. Read More >>